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International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

Different Therapeutic Aspects of Peroxisomes Proliferator-Activated Receptors

Abhishek Kumar , Chetna Jhagta , Shivali Singla , Sachin Goyal

International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-3,Issue-3, May - June 2019, Pages 1-20 , 10.22161/ijmpd.3.3.1

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Peroxisome proliferator-activated receptors (PPARs) was discovered in 1990 belong to the super family of steroid hormone receptors. Three subtypes of PPAR which have been identified so far- PPARα, PPARβ/δ, and PPARγ. Human peroxisome proliferator-activated receptors (hPPARs) were initially recognized as therapeutic targets for the development of drugs to treat metabolic disorders, such as diabetes and dyslipidemia but now they have been used in energy burning, dyslipidemia, diabetes, inflammation, Hepatic steatosis, liver cancer, diabetic neuropathy, atherosclerosis also. These are included in management of NIDDM, macrophage differentiation, adipose differentiation , anti-cancer, inhibition of TH2 cytokine production and rheumatoid arthritis. PPARβ/δ can use to treat Huntington’s disease, fertility, dyslipidemia. The functions of a third PPAR isoform and its potential as a therapeutic target are currently under investigation.

PPAR, Diabetes, Metabolic Disorder, rheumatoid arthritis etc.

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