• editor.aipublications@gmail.com
  • Track Your Paper
  • Contact Us
  • ISSN: 2456-7817

International Journal Of Engineering, Business And Management(IJEBM)

The mixing process in the production of paracetamol suspension and its stability

Alia Hassan Adi , Hussin Johari , Sabah Sibai


International Journal of Engineering, Business And Management(IJEBM), Vol-4,Issue-3, May - June 2020, Pages 51-56 , 10.22161/ijebm.4.3.1

Download | Downloads : 7 | Total View : 1448

Share

The mixing process is a common and important process in the chemical, food and pharmaceutical industries with the objective of producing suspensions and emulsions and increasing the process rate of mass and heat transfer. In this paper, the mixing process was studied during the production of paracetamol syrup in a new formula with a concentration of (10 g / 100 ml). For this purpose, a four-blade mixer was designed and the factors affecting the mixing process and the stability of the final product were studied including the mixing time and speed of rotation.

Paracetamol, Stability Studies, Mixing Process.

[1] Al-Jauhari,D.H.(2018). Technology and manufacturing processes. Syria: Al-Baath University Publications, (462).
[2] Abdulrahim, M.S.,Al-Samuraie, KH. F. (2015). Spectroscopy of paracetamol by nitrogen and conjugation with anthralnic acid.Iraq.Ibn Al-Haytham Journal of pure and applied sciences.
[3] Alemika, A. S., Bala, E., Sani, F., &Ramat, B. (2012). Analysis of Different brands of paracetamol 500 mg tablets used in Maiduguri. IRJP, 3(8), 165-167.
[4] Chandratilleke, G. R., Yu, A. B., &Bridgwater, J. (2012). A DEM study of the mixing of particles induced by a flat blade. Chemical Engineering Science, 79, 54-74.
[5] Behera, S., Ghanty, S., Ahmad, F., Santra, S., & Banerjee, S. (2012). UV-visible spectrophotometric method development and validation of assay of paracetamol tablet formulation. J Anal Bioanal Techniques, 3(6), 151-7.
[6] Cheremisinoff, N. P. (2000). Handbook of chemical processing equipment. Elsevier.
[7] Maheshwari, R. K., & Rajagopalan, R. (2012). Formulation and evaluation of paracetamol syrup made by mixed-solvency concept. Der Pharmacia Lettre, 4(1), 170-174.
[8] Doble, M. Perry’s Chemical Engineers’ Handbook.
[9] Dahlstrom, D. A., Bennett, R. C., Emmett, R. C., Harriott, P., Laros, T., Leung, W., & McCleary, C. (1997). Liquid-solid operations and equipment. Perry's Chemical Engineers' Handbook, 60-125.
[10] David, J. W. (1996). Effect of temperature on crystal growth and crystal properties of paracetamol. Journal of the Chemical Society, Faraday Transactions, 92(3), 439-444.
[11] McCabe, W. L., Smith, J. C., &Harriott, P. (1993). Unit operations of chemical engineering (Vol. 5, p. 154). New York: McGraw-hill.
[12] Mourad,M.Bitar,D.Y.(2014).Stability Studies of Levocetirizine and Pseudoephedrine Combination in Liquid Dosage Forms.Faculty of Pharmacy. University of Aleppo.
[13] Coulson, J. M., & Richardson, J. F. (2002). Coulson & Richardson's Chemical Engineering. V. 5. Solutions to the Problems in Chemical Engineering from Volume 2. Butterworth-Heinemann.