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International Journal Of Rural Development, Environment And Health Research(IJREH)

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  3. Vol-7,Issue-5, September - October 2023
  4. Hoodia Gordonii a herbal plant: A Review

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Hoodia Gordonii a herbal plant: A Review

Atul Ramesh Bonde , Rukhsana Mahiboob Pinjari


International Journal of Rural Development, Environment and Health Research(IJREH), Vol-7,Issue-5, September - October 2023, Pages 98-106,

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Article Info: Received: 12 Aug 2023; Received in revised form: 20 Sep 2023; Accepted: 02 Oct 2023; Available online: 08 Oct 2023

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According to statistics compiled by the World Health Organization (WHO), around one billion persons are overweight today, with another 300 million being obese. Based on these data, it is clear that obesity has become a huge international problem, impacting nations of all economic levels. Estimates predict that by 2025, Brazil would rank fifth in the world in obesity prevalence, up from its current rate of roughly 13%. Although certain herbal treatments are indicated for therapy, many other natural items are utilized without consideration to their safety or effectiveness in preventing or reducing weight gain. Notable among these is the African plant Hoodia gordonii, whose commercial powder was sold freely until it was banned in February 2007 by the Brazilian National Sanitary Surveillance Agency (ANVISA) due to a lack of scientific proofs of its efficacy and safety. Moreover, its putative association with leptin and insulin involved in neuroendocrine control of hunger and satiety is not well understood, nor is its method of action in suppressing desire and thirst.

Hoodia gordonii, obesity, herbal medicine, treatment.

[1] Associação Brasileira Para O Estudo Da Obesidade E Da Síndrome Metabólica (2010) Brazilian Association For The Study Of Obesity And Metabolic Syndrome. Available at www.abeso.org.br. Access in Feb 12.
[2] Agência Nacional De Vigilância Sanitária/National Sanitary Surveillance Agency (2007). Resolução RE 424 de 15 de fevereiro de 2007. Dispõe sobre a proibição da manipulação e comercialização, em todo o território nacional, da substância Hoodia gordonii, como medida de segurança por não atender às exigências regulamentares desta agência. Available at www.anvisa.org.br. Access in March 25.
[3] Apovian CM (2010). The causes, prevalence, and treatment of obesity revisited in 2009: what have we learned so far? Am. J. Clin Nutr. 91(suppl):277S–9S.
[4] Archer RH, VIctor JE (2003). Hoodia pilifera subs pillansii, Apocyanaceae: Asclepiadoideae. Curtis’s Botanical Magazine. 20(4):219-24.
[5] Auwerx J, Staels B (1998). Leptin. Lancet. Nature. 351:737–42. Avula B, Wang Y, Pawar RS, Shukla YJ, Khan I (2006). Determination of the appetite suppressant P57 in Hoodia gordonii plant extracts and dietary supplements by liquid chromatography/electrospray ionization mass spectrometry (LC-MSD-TOF) and LC-UV methods. J. AOAC Int. 89(3):606-11.
[6] Avula B, Wang Y, Pawar RS, Shukla YJ, Khan IA (2007). Chemical fingerprinting of Hoodia species and related genera: chemical analysis of oxypregnane glycosides using high-performance liquid chromatography with UV detection in Hoodia gordonii. J. AOAC Int. 90(6):1526-531.
[7] Avula B, Wang Y, Pawar RS, Shukla YJ, Smillie TJ, Khan IA (2008). A rapid method for chemical fingerprint analysis of Hoodia species, related genera and dietary supplements using UPLC-UV-MS. J. of Pharm. Biomed Anal. 48:722-31.
[8] Azeredo FS, Guimarães RI, Paula JR, Cunha LC (2005). Validação de técnica analítica em cromatografia em camada delgada comparativa para identificação de fármacos anorexígenos sintéticos em produtos fitoterápicos. Infarma. 17:5-6.
[9] Bays HE (2004). Current and investigational antiobesity agents and obesity therapeutic treatment targets. Obes. Res. 12(8):1197-211.
[10] Bednarek MA, Feigner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV (2000). Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J. Med. Chem. 43(23):4370-376.
[11] Bindra, J (2005). A Popular Pill's Hidden Danger. New York Times, New York, 26 abr.
[12] Brasil. Ministério da Saúde (2009). 13% two Brazilians are obese adults: given and trends, Brazil. Available at
[13] . Access in: Nov 10, 2009.
[14] Bray GA (2004). Medical consequences of obesity. J. Clin. Endocrinol. Metab. 89:2583–589.
[15] Bronner JS (2005). Appetite-suppressing, lipase-inhibiting herbal composition. United States Patent 20050276869. http://www.freepatentsonline.com/20050276869.html
[16] Bruyns PV (2005). Stapeliads of Southern Africa and Madagascar. Umdaus Press, Pretoria, vol 1, pp. 4–8.
[17] Carvalheira JBC, Zecchin HG, Saad MJA (2002). Ways of giving insulin Signaling. Arq Bras Endocrinol Metab. 46(4):419-25.
[18] CHIEN, YW (1996). Human insulin: Basic sciences to therapeutic uses. Drug Dev. Ind. Pharm. 22:753-89.
[19] CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC)
[20] USA (2010) Available at: Access in jan, 10, 2010.
[21] Chow JK, Akhtar Y, Isman MB (2005). The effects of larval experience with a complex plant latex on subsequent feeding and oviposition by the cabbage looper moth: Trichoplusia ni (Lepidoptera: Noctuidae). Chemoecology. 15:129-33.
[22] Considini RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR (1996). Serum immunoreactive leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334(5):292-95.
[23] Coutinho W (2007); Etiologia da obesidade. Revista ABESO. 30. Dall’Acqua S, Innocenti G (2007). Steroidal glyxosides from Hoodia gordonii. Steroids.;72:559-68.
[24] Elmquist JK, Maratos-Flier E, Saper CB, Flier JS (1998). Unraveling the central nervous system pathways underlying responses to leptin. Nat. Neurosci. 1:445–50.
[25] Erdmann J, Topsch R, Lippl F, Gussmann P, Schusdziarra V (2004). Postprandial response of plasma ghrelin levels to various test meals in relation to food intake, plasma insulin, and glucose. J. Clin. Endocrinol. Metabol. 89(6):3048-054.
[26] Fabricatore AN, Wadden TA, Rohay, JM, Pillitteri, JL, Shiffman S, Harkins AM, Burton SL (2008). Weight Loss Expectations and Goals in a Population Sample of Overweight and Obese US Adults. Obesity. 16:2445–450.
[27] Finkelstein EA, Trogdon JG, .Cohen JW, Dietz W (2009). Annual Medical Spending Attributable To Obesity: Payer-And Service-Specific Estimates. Health Affairs. 28(5):w822-w831. Flegal KM, Carroll MD, Ogden CL, Curtin LR (2010). Prevalence and Trends in Obesity Among US Adults, 1999-2008. Journal of American Medical Association (JAMA). 303(3):235-41.
[28] Francischi RPP, Pereira LO, Freitas CS, Klopfer M, SANTOS RC, VIEIRA P, Lancha Júnior AH (2000). Obesidade: atualização sobre sua etiologia, morbidade e tratamento. Rev. Nutr. 13(1):17-28.
[29] Friedman JM, Halaas JL (1998). Leptin and the regulation of body weight in mammals. Nature, 395(22):763-70.
[30] Gardiner Paul T, Heuer MA (2006). Diet supplement for causing rapid weight loss, controlling appetite, managing stress, supporting relaxation, combating fatigue and supporting mental well-being. United States. 20060286183 http://www.freepatentsonline.com/20060286183.html
[31] Gigante DP, Moura EC de, Sardinha LMV (2009). Prevalência de excesso de peso e obesidade e fatores associados. Revista de Saúde Pública. 43(supl.2):83-89.
[32] Hakkinen J, Horak RM, Maharaj V (2004). Gastric Acid Secretion. United States. 6808723B2. www.google.com/patents
[33] Hallschmid M, Schultes B (2009). Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders? Diabetologia. 52:2264–269.
[34] Halpern ZSC, Rodrigues MDB, Costa RF (2004). Determinantes fisiológicos do controle do peso e apetite. Revista de Psiquiatria Clínica. 31(4):150-53.
[35] Halpern A, Mancini MC (2005). Diabesity: Are Weight Loss Medications Effective? Treatments in Endocrinology. 4(2):65-74.
[36] Holt S (2006). Herbal compositions containing Hoodia. United States. WO2006079055A1. www.wipo.org.
[37] Houston DK, Cai J, Stevens J (2008). Overweight and Obesity in Young and Middle Age and Early Retirement: The ARIC Study. Obesity. 17:143–49.
[38] Hübner F, Tränkle U (2004). Available at: . Access in May 21, 2010.
[39] Janssen H, Swindells C, Gunning P, Wang W, Grün C, Mahabir K,
[40] Maharaj VJ, Apps PJ (2008). Quantification of appetite suppressing steroid glycosides from Hoodia gordonii in dried plant material, purified extracts and food products using HPLC -UV and HPLC–MS methods. Analytica Chimica Acta. 617:200–07.
[41] Kojima M, Hosoda H, Date Y (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 402:656-60.
[42] Kojima M, Hosoda H, Matsuo H, Kangawa K (2001). Ghrelin: discovery of the natural endogenous ligand for the growth-hormone secretagogue receptor. Trends Endocrinol. Metabol. 12(3):118-22.
[43] Konturek SJ, Konturek JW, Pawlik T, Brzozowki T (2004). Brain-gut axis and its role in the control of food intake. Journal of Physiology and Pharmacology. 5:137-54.
[44] MaClean DB, Luo L (2004). Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside. Brain Research.; 1020:1 –11.
[45] MacLEAN, DB (2006). Modulation of ATP production or content in the hypothalamus. United States Patent 20060233861 http://www.freepatentsonline.com/20060233861.html
[46] Mohlapo TD, Ng’ambi JW, Norris D, Malatje MM (2009). Effect of Hoodia gordonii meal supplementation at finisher stage on productivity and carcass characteristics of Ross 308 broiler chickens. Tropical Animal Health and Production. 41:1591–596.
[47] Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K (2001). A role for ghrelin in the central regulation of feeding. Nature, 409(6817):194-98.
[48] OGDEN CL, CARROLL MD, CURTIN LR (2006). Prevalence of overweight and obesity in the United States, 1999–2004. JAMA.; 295:1549–555. ORGANIZAÇÃO PANAMERICANA DE SAÚDE sobre alimentação saudável, atividade física e saúde. OPAS/OMS, Brasília, 60p. www.who.int. Access in Jan 12.
[49] Popkin BM (2010). Recent dynamics suggest selected countries catching up to US obesity. American Journal of Clinical Nutrition. 91(suppl):284S–8S
[50] Pawar RS, Shukla YJ, Khan SI, Avula B (2007) New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii. Steroids. 72(6-7):524-34.
[51] Rader JI, Delmonte P, Trucksess MW (2007). Recent studies on selected botanical dietary supplement ingredients. Anal Bioanal Chem. 389:27–35.
[52] RASKIN, ILYA; (Manalapan, NJ), O'NEAL,; JOSEPH M. III; 2006. Appetite-suppressing compositions and methods. United States. 20060084638 http://www.freepatentsonline.com/20060084638.html
[53] Reseland JE, Anderssen SA, Sovoll K, Hjermann I, Urdal P, Holme I Et AL (2001). Effect of long-term changes in diet and exercise on plasma leptin concentrations. American Journal of Clinical Nutrition. 73(2):240-45.
[54] Rifkin CH (2005). Appetite satiation and hydration beverage. United States. 20050276839.http://www.freepatentsonline.com/20050276839.html
[55] Romero CEM, Zanesco A (2006). O papel dos hormônios leptina e grelina na gênese da obesidade. Revista de Nutrição. 19(1):85-91.
[56] Salbe AD, Tshop MH, Delparigi A, Venti C, Tataranni PA (2004). Negative relationship between fasting plasma ghrelin concentrations and ad libitum food intake. J. Clin. Endocrinol. Metabol. 89(6):2951-956.
[57] Schwartz MV (2000). Staying slim with insulin in mind. Science. 289:2066-067.
[58] Shukla YJ, Pawar RS, Ding Y, LI X, Ferreira D, Khan IA (2009). Pregnane glycosides from Hoodia gordonii. Phytochemistry. 70:67
[59] SOCIEDADE BRASILEIRA DE ENDOCRINOLOGIA E METABOLOGIA (SBEM) (2010). Available at: www.endocrino.org.br. Access in Jan 15.
[60] Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford MLJ (1997). Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature. 390(4):521-25.
[61] Thande NK, Hurstak EE, Sciacca RE, Giardina EV (2008). Management of Obesity: A Challenge for Medical Training and Practice. Obesity. 17:107–13.
[62] Tulp OL, Harbi NA, Mihalov J, Dermarderosian A (2001). Effect of Hoodia plant on food intake and body weight in lean and obese LA/ Ntul//-cp rats. FASEB Journal. 15:A404.
[63] Tulp OL, Harbi NA, Mihalov J, Dermarderosian A (2002). Effect of Hoodia Plant on Weight Loss in Congenic ObeseLA/Ntul//-cp rats. FASEB Journal.; 16(4):A654.
[64] UNIVERSITY OF HAWAII. Available at:. Access Jul. 15 Jul, 2007.
[65] Van Heerden FR, Vleggaar R, Horak R M, Learmonth RA, Maharaj V, Whittal R D (2004). Use of extracts from Hoodia gordonii and Hoodia lugardii for the preparation of a medicament for use in the suppression of appetite. CSIR (ZA). EP1438965 http://www.freepatentsonline.com/EP1438965.html
[66] Van Heerden FR (2010) Hoodia gordonii: A natural appetite suppressant. Journal of Ethnopharmacology.119:434–37.
[67] Van Heerden FR, Horak RM, Maharaj VJ, Vleggaar R, Senabe JV, Gunning P J (2007). An appetite suppressant from Hoodia species. Phytochemistry.68:2545–553.
[68] Verdegem PJE, Hughes SF, Hedges C A, Bangerter PG (2008). Method and composition for providing controlled delivery of biologically active substances. United States Patent Application 20080305096 http://www.freepatentsonline.com/2008030509.html
[69] Woods SC, Seeley RJ, Porte JR, SCHWARTZ DMW (1998). Signals that regulate food intake and energy homeostasis. Science. 280:1378-383.
[70] WORLD HEALTH ORGANIZATION – WHO (2006). Bulletin of the World Health Organization. 84(5):345.
[71] WORLD HEALTH ORGANIZATION – WHO (2003). Bulletin of the World Health Organization. 81(5):382.ORGANIZAÇÃO MUNDIAL DA SAÚDE (OMS) (2003). Available at: (OPAS)/ORGANIZAÇÃO MUNDIAL DE SAÚDE (OMS) (2003). Doenças crônico-degenerativas e obesidade: estratégia mundial

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