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International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

Uterine Artery Doppler and Prediction of Preeclampsia

Dr. Trefa Yousif , Dr. Sawen Khasrow Dizay


International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-5,Issue-4, July - August 2021, Pages 1-8 , 10.22161/ijmpd.5.4.1

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Article Info: Received: 25 May 2021; Received in revised form: 19 Jun 2021; Accepted: 30 Jun 2021; Available online: 07 Jul 2021

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The purpose of this study was to determine the accuracy of screening for pregnancy hypertension disorders using maternal serum biomarkers and uterine artery Doppler during the first trimester. At 11-13 weeks, uterine artery Doppler and serum measurements were taken from prospectively enrolled nulliparous women. In this study, maternal features, uterine artery Doppler imaging, and serum placental biomarkers (pregnancy-associated plasma protein-A, Inhibin-A, placental protein, A disintegrin and metalloprotease, free B-hCG, placental growth factor) were all collected and evaluated. Twenty women (2.2 percent) experienced prenatal hypertension, and forty women (4.5 percent) developed preeclampsia, with nine (1.0 percent) developing early-onset preeclampsia and sixteen (1.8 percent) developing severe preeclampsia, according to the findings. A combination screening model that included clinical features, pregnancy-associated plasma protein-A, Inhibin-A, and placental growth factor was found to be effective in detecting 75 percent of early-onset preeclampsia with a false-positive rate of 10 percent. Uterine artery Doppler, placental protein, A disintegrin and metalloprotease were all found to have no effect on diagnosis accuracy after adjusting for clinical factors. When combined with first-trimester maternal serum biomarkers (pregnancy-associated plasma protein-A, Inhibin-A, and placental growth factor), a combination of clinical features and placental growth factor can give an accurate screening for early-onset preeclampsia in nulliparous women.

uterine artery Doppler, preeclampsia, screening, Erbil, Kurdistan Region of Iraq.

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