• editor.aipublications@gmail.com
  • Track Your Paper
  • Contact Us
  • ISSN: 2456-8015

International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

Uterine Artery Doppler and Prediction of Preeclampsia

Dr. Trefa Yousif , Dr. Sawen Khasrow Dizay


International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-5,Issue-4, July - August 2021, Pages 1-8 , 10.22161/ijmpd.5.4.1

Download | Downloads : 4 | Total View : 298

Article Info: Received: 25 May 2021; Received in revised form: 19 Jun 2021; Accepted: 30 Jun 2021; Available online: 07 Jul 2021

Share

The purpose of this study was to determine the accuracy of screening for pregnancy hypertension disorders using maternal serum biomarkers and uterine artery Doppler during the first trimester. At 11-13 weeks, uterine artery Doppler and serum measurements were taken from prospectively enrolled nulliparous women. In this study, maternal features, uterine artery Doppler imaging, and serum placental biomarkers (pregnancy-associated plasma protein-A, Inhibin-A, placental protein, A disintegrin and metalloprotease, free B-hCG, placental growth factor) were all collected and evaluated. Twenty women (2.2 percent) experienced prenatal hypertension, and forty women (4.5 percent) developed preeclampsia, with nine (1.0 percent) developing early-onset preeclampsia and sixteen (1.8 percent) developing severe preeclampsia, according to the findings. A combination screening model that included clinical features, pregnancy-associated plasma protein-A, Inhibin-A, and placental growth factor was found to be effective in detecting 75 percent of early-onset preeclampsia with a false-positive rate of 10 percent. Uterine artery Doppler, placental protein, A disintegrin and metalloprotease were all found to have no effect on diagnosis accuracy after adjusting for clinical factors. When combined with first-trimester maternal serum biomarkers (pregnancy-associated plasma protein-A, Inhibin-A, and placental growth factor), a combination of clinical features and placental growth factor can give an accurate screening for early-onset preeclampsia in nulliparous women.

uterine artery Doppler, preeclampsia, screening, Erbil, Kurdistan Region of Iraq.

[1] Tianthong, W., & Phupong, V. (2021). Serum hypoxia-inducible factor-1α and uterine artery Doppler ultrasound during the first trimester for prediction of preeclampsia. Scientific Reports, 11(1), 1-7.
[2] Oancea, M., Grigore, M., Ciortea, R., Diculescu, D., Bodean, D., Bucuri, C., ... & Mihu, D. (2020). Uterine artery doppler ultrasonography for first trimester prediction of preeclampsia in individuals at risk from low-resource settings. Medicina, 56(9), 428.
[3] Prakansamut, N., & Phupong, V. (2019). Serum SHARP1 and uterine artery Doppler for the prediction of preeclampsia. Scientific reports, 9(1), 1-7.
[4] Yu, N., Cui, H., Chen, X., & Chang, Y. (2017). First trimester maternal serum analytes and second trimester uterine artery Doppler in the prediction of preeclampsia and fetal growth restriction. Taiwanese journal of obstetrics and Gynecology, 56(3), 358-361.
[5] Cui, S., Gao, Y., Zhang, L., Wang, Y., Zhang, L., Liu, P., ... & Chen, J. (2017). Combined use of serum MCP-1/IL-10 ratio and uterine artery Doppler index significantly improves the prediction of preeclampsia. Clinica Chimica Acta, 473, 228-236.
[6] Maged, A. M., Saad, H., Meshaal, H., Salah, E., Abdelaziz, S., Omran, E., ... & Katta, M. (2017). Maternal serum homocysteine and uterine artery Doppler as predictors of preeclampsia and poor placentation. Archives of gynecology and obstetrics, 296(3), 475-482.
[7] Soongsatitanon, A., & Phupong, V. (2020). Prediction of preeclampsia using first trimester placental protein 13 and uterine artery Doppler. The Journal of Maternal-Fetal & Neonatal Medicine, 1-6.
[8] Pedroso, M. A., Palmer, K. R., Hodges, R. J., Costa, F. D. S., & Rolnik, D. L. (2018). Uterine artery Doppler in screening for preeclampsia and fetal growth restriction. Revista brasileira de ginecologia e obstetricia, 40, 287-293.
[9] Rashid, M. N., Kari, M., Rashid, R., Rana, M. A., Amjad, A., & Hafeez, M. M. (2020). Uterine artery doppler indices as predictive measures for the pre-eclampsia and intrauterine growth restriction. Biological and Clinical Sciences Research Journal, 2020(1), e023-e023.
[10] Salem, M. A. A., & Ammar, I. M. M. (2018). First-trimester uterine artery pulsatility index and maternal serum PAPP-A and PlGF in prediction of preeclampsia in primigravida. The Journal of Obstetrics and Gynecology of India, 68(3), 192-196.
[11] Litwińska, E., Litwińska, M., Oszukowski, P., Szaflik, K., & Kaczmarek, P. (2017). Combined screening for early and late pre-eclampsia and intrauterine growth restriction by maternal history, uterine artery Doppler, mean arterial pressure and biochemical markers. Advances in Clinical and Experimental Medicine, 26(3), 439-448.
[12] Okwudire, E. G., Atalabi, O. M., & Ezenwugo, U. M. (2019). The use of uterine artery doppler indices for prediction of pre-eclampsia in Port-Harcourt, Nigeria. Nigerian Postgraduate Medical Journal, 26(4), 223.
[13] Allen, R., & Aquilina, J. (2018). Prospective observational study to determine the accuracy of first-trimester serum biomarkers and uterine artery Dopplers in combination with maternal characteristics and arteriography for the prediction of women at risk of preeclampsia and other adverse pregnancy outcomes. The Journal of Maternal-Fetal & Neonatal Medicine, 31(21), 2789-2806.
[14] Razavi, M., Rashidi Fakari, F., Jafari, F. S., Farzaneh, F., & Sargolzaei, N. (2019). The role of uterine artery doppler ultrasound in the second trimester in predicting preeclampsia. International Journal of Pediatrics, 7(5), 9405-9411.
[15] Ratiu, D., Hide-Moser, K., Morgenstern, B., Gottschalk, I., Eichler, C., Ludwig, S., ... & Thangarajah, F. (2019). Doppler indices and notching assessment of uterine artery between the 19th and 22nd week of pregnancy in the prediction of pregnancy outcome. in vivo, 33(6), 2199-2204.