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International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

The Microbiome’s Impact on Human Health: Unraveling the Gut-Brain Connection

Jalla Ram

International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-5,Issue-4, July - August 2021, Pages 22-26 , 10.22161/ijmpd.5.4.4

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Article Info: Received: 11 Jul 2021; Received in revised form: 05 Aug 2021; Accepted: 14 Aug 2021; Available online: 24 Aug 2021


The human body hosts a diverse community of microorganisms known as the microbiome, with a significant population residing in the gut. Recent scientific discoveries have illuminated a fascinating interplay between the gut microbiome and the brain, giving rise to the concept of the gut-brain connection. This abstract encapsulates a comprehensive study exploring the intricate impact of the microbiome on human health, specifically focusing on the emerging understanding of the gut-brain axis. The human microbiome, a complex ecosystem of microorganisms inhabiting various body sites, has garnered increasing attention for its pivotal role in health and disease. Within this vibrant microbiome, the gut stands out as a major hub, hosting a myriad of microorganisms that contribute to digestion, immune function, and overall well-being. This study delves into the profound impact of the gut microbiome on human health, unraveling the intricate web of the gut-brain connection. A multidisciplinary approach will be adopted, involving literature reviews, molecular studies, and clinical investigations. Microbiome sequencing techniques will be used to analyze gut microbiome composition in relation to mental health outcomes. Neuroscientific methodologies will be employed to elucidate the neural pathways and biochemical signaling underlying the gut-brain communication.

Human, Health, Biochemical, microorganisms, Molecular, microbiome

[1] Korpela K, de Vos WM. Early life colonization of the human gut: microbes matter everywhere. Curr Opin Microbiol 2018;44:70–8.
[2] Korpela K, Helve O, Kolho K-L, et al. Maternal fecal microbiota transplantation in Cesarean-Born infants rapidly restores normal gut microbial development: a proof-of-concept study. Cell 2020; 183:324–34.
[3] Lloyd-Price J, Mahurkar A, Rahnavard G, et al. Strains, functions and dynamics in the expanded human microbiome project. Nature 2017; 550:61–6.
[4] Barlow JT, Leite G, Romano AE, et al. Quantitative sequencing clarifies the role of disruptor taxa, oral microbiota, and strict anaerobes in the human small-intestine microbiome. Microbiome 2021; 9:214.
[5] Seekatz AM, Schnizlein MK, Koenigsknecht MJ, et al. Spatial and temporal analysis of the stomach and small-intestinal microbiota in fasted healthy humans. mSphere 2019;4:e00126–19.
[6] Leite GGS, Weitsman S, Parodi G, et al. Mapping the segmental Microbiomes in the human small bowel in comparison with stool: a REIMAGINE study. Dig Dis Sci 2020; 65:2595–604.
[7] Zoetendal EG, Rajilic-Stojanovic M, de Vos WM. High-Throughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut 2008; 57:1605–15.
[8] Qin J, Li R, Raes J, et al. A human gut microbial gene Catalogue established by metagenomic sequencing. Nature 2010; 464:59–65.
[9] Rajilić-Stojanović M, de Vos WM. The first 1000 cultured species of the human gastrointestinal microbiota. FEMS Microbiol Rev 2014; 38:996–1047.
[10] Li J, Jia H, Cai X, et al. An integrated catalog of reference genes in the human gut microbiome. Nat Biotechnol 2014; 32:834–41.
[11] van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 2013; 368:407–15.
[12] Lynch SV, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med 2016; 375:2369–79.
[13] Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol 2021; 19:55–71.
[14] Hanssen NMJ, de Vos WM, Nieuwdorp M. Fecal microbiota transplantation in human metabolic diseases: from a murky past to a bright future? Cell Metab 2021; 33:1098–110.
[15] Wang R, Tang R, Li B, et al. Gut microbiome, liver immunology, and liver diseases. Cell Mol Immunol 2021; 18:4–17. 16 O’Grady J, Murphy CL, Barry L, et al