• editor.aipublications@gmail.com
  • Track Your Paper
  • Contact Us
  • ISSN: 2456-8015

International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

Synthesis & Pharmacological Activity of Cytotoxicity Assay of Coumarins SVCM1-SVCM7

Swapnil Verma , Priya Jain


International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-7,Issue-5, October - December 2023, Pages 1-7 , 10.22161/ijmpd.7.5.1

Download | Downloads : 4 | Total View : 317

Article Info: Received: 09 Aug 2023; Received in revised form: 10 Sep 2023; Accepted: 20 Sep 2023; Available online: 01 Oct 2023

Share

The therapeutic properties of natural and synthetic compounds against human illnesses have attracted a lot of interest. The pharmacological and biological effects of coumarins are widely exploited in medicine; they include anti-inflammatory, anticoagulant, antihypertensive, anticonvulsant, antioxidant, antibacterial, and neuroprotective properties. Signaling pathways affecting many cellular functions may also be modulated by coumarin derivates. Whether or not a coumarin has pharmacological, biochemical, or therapeutic characteristics is dependent on the nature of the replacement surrounding the coumarin core structure. The capacity to kill, repel, or otherwise impact the development of Anopheles arabiensis mosquitoes was evaluated using seven synthetic halogenated coumarins (SVCM1-SVCM7). The compounds SVCM1-SVCM7 were evaluated for their bactericidal and fungicidal activities using the disc diffusion method.

coumarin; antineoplastic; cancer therapy; docking.

[1] Kamuhabwa, A., Nshimo, C. & De Witte, P. 2000. Cytotoxicity of some medicinal plant extracts used in Tanzanian traditional medicine. Journal of Ethnopharmacology, 70, 143-149.
[2] Kang, M. H. & Reynolds, C. P. 2009. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clinical Cancer Research, 15, 1126-1132.
[3] Kasibhatla, S. & Tseng, B. 2003. Why target apoptosis in cancer treatment? Molecular Cancer Therapeutics, 2, 573-580.
[4] Kaur, R. & Rup, P. 2002. Evaluation of regulatory influence of four plant growth regulators on the reproductive potential and longevity of melon fruit fly (Bactrocera cucurbitae). Phytoparasitica, 30, 224-230.
[5] Kini, S. G., Choudhary, S. & Mubeen, M. 2012. Synthesis, docking study and anticancer activity of coumarin substituted derivatives of benzothiazole. Journal of Computational Methods in Molecular Design, 2, 51-60.
[6] Kontogiorgis, C. A. & Hadjipavlou-Litina, D. J. 2005. Synthesis and antiinflammatory activity of coumarin derivatives. Journal of medicinal chemistry, 48, 6400-6408.
[7] Kostova, I. 2005. Synthetic and natural coumarins as cytotoxic agents. Current Medicinal Chemistry-Anti-Cancer Agents, 5, 29-46.
[8] Krishnaraju, A. V., Rao, T. V., Sundararaju, D., Vanisree, M., Tsay, H.-S. & Subbaraju,
[9] G. V. 2005. Assessment of bioactivity of Indian medicinal plants using Brine shrimp (Artemia salina) lethality assay. International Journal of Engineering Science, 3, 125- 134.
[10] Kumar, P. S., Ghosh, G., Rout, S. & Paul, D. 2013. Synthesis and antimicrobial evaluation of some novel 4-hydroxy coumarin derivatives bearing azo moiety. Rasayan Journal of Chemistry, 6, 147-152.
[11] Lacy, A. & O'kennedy, R. 2004. Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer. Current Pharmaceutical Design, 10, 3797-3811.
[12] Lake, B. 1999. Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Food and Chemical Toxicology, 37, 423-453.
[13] Letteron, P., Descatoire, V., Larrey, D., Tinel, M., Geneve, J. & Pessayre, D. 1986. Inactivation and induction of cytochrome P-450 by various psoralen derivatives in rats. Journal of Pharmacology and Experimental Therapeutics, 238, 685-692.
[14] Lopez-Gonzalez, J. S., Prado-Garcia, H., Aguilar-Cazares, D., Molina-Guarneros, J. A., Morales-Fuentes, J. & Mandoki, J. J. 2004. Apoptosis and cell cycle disturbances induced by coumarin and 7-hydroxycoumarin on human lung carcinoma cell lines. Lung Cancer, 43, 275-283.
[15] Liu, R., Sun, Q., Shi., Y. & Kong, L. 2005. Isolation and purification of coumarin compounds from the root of Peucedanum decursivum (Miq.) Maxim by high-speed counter-current chromatography.Journal of Chromatography, 1076, 127-132