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International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

Synthesis and Characterization of Glimepiride Yttrium Complex

I.E. Otuokere , K.C. Amadi

International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-1,Issue-2, July - August 2017, Pages 10-14 ,

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Glimepiride is a sulphonylurea drug that is active in the management of non-insulin dependent diabetes mellitus (NIDDM). It stimulates the release of insulin by inhibiting the efflux of K+ (K+ channel blockers) from pancreatic ß-cells. Glimepiride yttrium complex was synthesized by reaction of glimepiride with yttrium nitrate pentahydrate (Y(NO3)3.6H2O). The metal complex was characterized based on elemental analysis, UV, IR and 13C NMR spectroscopy. The result of the elemental analysis was found to be in agreement with the calculated values. The ligand’s electronic spectrum showed intra ligand charge transfer (ILCT), resulting from the presence of the chromophores present in the ligand. The electronic spectrum of the complex formed suggested intra ligand charge transfer (ILCT), ligand to metal charge transfer (LMCT), and d-d transition. IR spectrum of the yttrium complex showed the complexation of the metal ion to two carbonyls and one amino group. This further showed that the glimepiride acted as bidentate ligand. In the 13C NMR spectrum, it is evident that the pyrrole ring was involved in coordination to the metal ion. Tetrahedral geometry was proposed for the complex.

Glimepiride, metal complex, spectrum, synthesis.

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