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International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

Study of Sensory Nerve Conduction Abnormalities in Hypothyroid Patients

Dr. Garima Bafna , Sarita Sharma , Gayatri Darger


International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-4,Issue-1, January - February 2020, Pages 4-8 , 10.22161/ijmpd.4.1.2

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Introduction -Thyroid hormones have effects virtually on every organ system in the body including central and peripheral nervous system. Hypothyroidism is a condition associated with low levels of thyroid hormones with raised TSH. Peripheral neuropathy is one of the manifestations of the hypothyroidism. Aims and objectives-The present study aimed to evaluate sensory nerve conduction defects in hypothyroid patients compared to non-hypothyroid controls. Methods-The study was conducted on 100 subjects, 50 hypothyroid patients and 50 normal Subjects between the age group of 18- 60 years, coming to JLN Hospital OPD in Neurophysiology Lab using EMG NCV EP machine by Recorders and Medicare Systems, model RMS SALUS 4C. The parameters (latency, and nerve conduction velocity) of sensory component of nerves (Median, Ulnar and Sural) compared between cases (Hypothyroidism) and controls (non hypothyroid). The patient was made to lie down on the couch and surface electrodes were fixed over the skin which was on the nerve and supplying muscle. By the stimulating electrodes, the nerve was stimulated at the distal end. Results-56 % of median nerve was affected in hypothyroidism. 34 % of sural nerve was affected in hypothyroidism. Conclusion- The median nerve is the most common affected sensory nerve .Estimation of the nerves conduction values can be considered as a useful parameter in the diagnosis and evaluation of the neuropathy in hypothyroid patients.

Hypothyroidism, Nerve conduction study, Peripheral neuropathy.

[1] Arthur C. Guyton John E. Hall,In : insulin glucagon and DM, Text book of Medical Physiology, 11 th edition, 2006 Saunders, Philadelphia:972
[2] Lewis E. Braverman, In: The heritage of the thyroid; A brief history, Werner & I ingbar’s the thyroid a fundamental and clinical text, Tenth edition, 2013, Wolters Kluwer/ Lippincott Williams & Wilkins. Pg- 1.
[3] John A.H.Wass, Stephen M. Shalet and Jayne A.Franklyn In: Subclinical hypothyroidism; Oxford Textbook of Endocrinology and Diabetes. 2002. Oxford University Press. Pg 286.
[4] GulbunYuksel, Geysu Karlikaya, Tulin Tanridag, Onder US, GulserenAkyuz. Nerve Conduction Studies, SEP and Blink Reflex in 103 recently diagnosed, Untreated Thyroid Disease Patients, Journal of Neurological Sciences 2007, volume 24, Number 1, Page 007-015.
[5] Golding NN. Hypothyroidism presenting with musculoskeletal symptoms. Ann. rheum. Dis., 1970: 10-14.
[6] RaffaelloNemni , Edo Bottacchi, Rarraella Fazio, Angelo Mamoli, Massimo Corbo, Massimo Camerlingo, Giuseppe Galardi , Luciano Erenbourg, Nicholas Canal. Polyneuropathy in hypothyroidism: clinical, electrophysiological and morphological findings in four cases. Journal of Neurology, Neurosurgery and Psychiatry 1987; 50: 1454-1460.
[7] Marcia W .Cruz; Mauro Tendrich, Mario Vaisman, Sergio A.P. Novis. Electroneuromyography and neuromuscular findings in 16 primary hypothyroid patients; Arq Neuropsiquiatr 1996, 54(1): 12-18.
[8] Somay G, Oflaxoglu B, Us O, Surardamar A. Neuromuscular status of thyroid diseases: a prospective clinical and electrodiagnostic study. Electromyogr Clin Neurophysiol.2007 Mar-Apr; 47(2):67-78.
[9] Yeasmin S , Begum N, Befum S, Rahman SMH. Sensory Neuropathy in Hypothyroidism: Electrophysiological and Clinical Findings. Journal of Bangaladesh Society of Physiology.2007 Dec ;( 2):1-6.
[10] EttoreBeghi, Maria Lelodovici, Graziella Bogliun, Vottorio Crespi, Felice Paleari, PIERLUIGI Gamba, Maurizio Capra, Michele Zarrelli. Hypothyroidism and polyneuropathy. Journal of Neurology, Neurosurgery and Psychiatry 1989; 52:1420 – 1423.
[11] Rao S N, Katiyar B C, Nair K R P, Misra S Neuromuscular status in hypothyroidism. Acta Neuro Scand 1980; 61:167-77.
[12] Fincham R W ,Cape CA Neuropathy in myxedema. Arch Neurol 1969;19(464-466)
[13] Yeasmin S , Begum N, Befum S, Rahman SMH. Sensory Neuropathy in Hypothyroidism: Electrophysiological and Clinical Findings. Journal of Bangaladesh Society of Physiology.2007 Dec ;( 2):1-6.
[14] Ruurd F Duyff, Joan Van den Bosch, D Martin Laman, Bert-Jan Potter van Loon. Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study. Journal of Neurology, Neurosurgery, Psychiatry 2000;68:750-755.
[15] Pollard JD, McLeod JG, Honnibal TGA, Verheijden MA. Hypothyroid polyneuropathy. JNeurolSci 1982;53:461-71
[16] Colin D. Binnie, Ray Cooper, C.J.Fowler and B. M. Tedman In: Clinical neurophysiology, volume I . Second edition 2004.EMG, Nerve conduction and Evoked potentials. page 1
[17] Giroud M, Tenenbaum D, D’Athis P, Dumas R, Nivelon JL. neurophysiological study of peripheral nerves in newborn infants with congenital hypothyroidism. Value in the surveillance of replacement therapy. Arch FrPediatr. 1988 Mar;45(3):175-9