IJMPD | Polygonum Persicaria (Linn.) and its Active Principle have a hepatoprotective and antioxidant effect on carbon tetrachloride-induced toxicity in rats

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Polygonum Persicaria (Linn.) and its Active Principle have a hepatoprotective and antioxidant effect on carbon tetrachloride-induced toxicity in rats

Mohd Shafi Dar , Deepak Kumar Mittal , Shazia Tabasum , Rafeeq Ahmad Najar , Abu Tahir

International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-6,Issue-2, March - April 2022, Pages 1-7 , 10.22161/ijmpd.6.2.1

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Article Info: Received: 30 Jan 2022; Received in revised form: 20 Feb 2022; Accepted: 01 Mar 2022; Available online: 08 Mar 2022

Abstract:

The aim of this analysis was to see whether the aqueous extract of the roots of Polygonum persicaria (PP) and its active principle, Tannic Acid (TA), had a hepatoprotective and antioxidant effect in rats provided Carbon tetrachloride (1.5 ml/kg, i.p). Twenty albino wistar rats were divided into five groups: control, CCl4-induced hepatotoxicity, hepatotoxicity with Polygonum persicaria and Tannic acid, and a normal group given 100 mg/kg silymarin. After 14 days, the rats were sacrificed. Toxicity testing was carried out on 12 rats. They were randomly allocated to one of three groups: control, Polygonum persicaria 200 mg/kg (B.wt), and Tannic acid 200 mg/kg (B.wt). The amounts of liver homogenate enzymes (glutathione peroxidase, glutathione-S-transferase, glucose-6-phosphatase dehydrogenase, and glutathione reductase enzymes) were greatly restored by extracts of PP and TA at the tested concentrations, supporting the biochemical results. Tannic acid, in contrast to Polygonum persicaria, tends to have a greater liver defensive role toward carbon tetrachloride-induced hepatotoxicity, as well as antioxidant properties and mild anticancer activity against cell viability at higher concentrations. The histological alterations in the liver indicated the injury. Polygonum persicaria & its active principle Tannic acid has strong antioxidant properties as well as hepatoprotective effects against CCl4-induced hepatotoxicity, as demonstrated by these observations.

Keywords:

Polygonum persicaria, Tannic acid, antioxidant, Hepatoprotective, Carbon tetrachloride, Anti cancerous, Silymarin, & Histopathology.

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