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International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

Investigation of the Antiulcer Effect of Xsanthoparmelia Somloensis in Rats Induced with Indomethacin

Yasin Berktas, Ömercan Alat, Mohammad Alhilal, Özlem Aydin Berktas, Mesut Halici


International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-9,Issue-2, April - June 2025, Pages 7-14 , 10.22161/ijmpd.9.2.2

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Article Info: Received: 20 Apr 2025; Received in revised form: 14 May 2025; Accepted: 17 May 2025; Available online: 24 May 2025

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The gastroprotective effect of Xsanthoparmelia somloensis was investigated in an experimentally in rats. This study was planned to investigate the biochemical changes in ulcer-induced mice. 24 wistar rats were divided into four different groups of 6 rats each. The indomethacin (IND), lichen extract and ranitidine were given orally at appropriate doses to the rats which were fasted for 24 hours before the experiment. The IND was administered orally again 5 minutes after the end of all treatments. The mice were sacrificed with high dose anaesthetic after a 6-hour waiting period. Biochemical parameters and antioxidant activity were determined in the stomach tissues. The catalase (CAT), myeloperoxidase (MPx), superoxide dismutase (SOD), glutathione peroxidase (GPx) enzyme activities and glutathione (GSH) and lipid peroxidase (LPO) levels were measured in gastric tissues removed from mice. In the data obtained, a decrease in CAT, MPx enzymes and an increase in SOD and GPX enzyme activities were determined when compared with IND-treated tissues. GSH level increased while LPO level decreased. The protective effect of the extract on ulcerated tissues caused by IND was assessed, and it can be concluded that it provides protection more than ranitidine utilized as a positive control at the given dosage.

antioxidant enzymes, lichen, lipid peroxidation, ulcer, Xsanthoparmelia somloensis

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