• editor.aipublications@gmail.com
  • Track Your Paper
  • Contact Us
  • ISSN: 2456-8015

International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

Medicinal Properties of Bioactive Compounds Identified in the acetone extract of Daedalea elegans using Gas Chromatography – Mass Spectrometry

Grace Oluwatoyin Mensah-Agyei , Seyi Samson Enitan , Adetiloro Esther Omolara


International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-5,Issue-5, September - October 2021, Pages 1-10 , 10.22161/ijmpd.5.5.1

Download | Downloads : 5 | Total View : 340

Article Info: Received: 11 Jul 2021; Received in revised form: 02 Sep 2021; Accepted: 10 Sep 2021; Available online: 15 Sep 2021

Share

Daedalea elegans is a Nigerian wild (non-edible) higher fungus with great potentials in the pharmaceutical, textile, cosmetics and food industry. This current study investigates the bioactive compounds that can be found in the acetone extract of D. elegans using Gas Chromatography-Mass Spectrometry (GC-MS). There were twenty-eight compounds identified to be present in the acetone extract of the fungi under study and these are Benzoic acid (0.40%), Nonanoic acid (0.14%), Oxetane, 2,2,4-trimethyl- (0.28%), n-Decanoic acid (0.09%), Phthalimide (0.44%) Dodecanoic acid (0.24%), E-2-Hexenyl benzoate (0.21%), 2,4-Difluorobenzene, 1-benzyloxy- (0.16%), Tetratetracontane (0.55%), Isopropylphosphonic acid, fluoroanhydryde (0.28%), Benzene, (1-methylundecyl)- (0.21%), Tetradecanoic acid (0.76%), Cyclohexanepropanol, .alpha.,2,2,6-tetrame (0.56%), Pentadecanoic acid (0.71%), E-2-Hexenyl benzoate (0.32%), Pentadecanoic acid (0.97%), 1-Decanol, 2-hexyl- (0.46%), 9-Tetradecenal, (Z) (1.67), n-Hexadecanoic acid (23.59%) is the second most abundant, Phthalic acid, butyl undecyl ester (1.08%), Eicosanoic acid (0.79%), 9,12-Octadecadienoic acid (Z,Z)- (44.64%) was the highest in quantity, Octadecanoic acid (6.98%), Bis(2-ethylhexyl) phthalate (2.64%), 2,2,4-Trimethyl-3-(3,8,12,16-tetramethyl-heptadeca-3,7,11,15-tetraenyl)-cyclohexanol (1.95%), 9(11)-Dehydroergosteryl benzoate (8.37%), 9(11)-Dehydroergosteroltosylate (1.28%), 4,6-Decadienal, 8-ethyl-10-[4-hydroxy-8-(2-hydroxypropyl)-3,9 (0.22%). These compounds possess activities which includes but not limited to cancer chemotherapy, antifeedant against pine weevil, antifungi agent in topical therapeutic preparation, anti-inflammatory, immunomodulatory, anti-convulsant, antioxidants, hypocholesterolemic, anti-androgenic, nematicide, analgesic, intermediate for food-grade additives, lubricants, greases, rubber, dyes and plastic, antineoplastic agent, biosynthesis of prostaglandins and cell membrane to mention a few. This study has been able to show that D. elegans is a good source of bioactive compounds with great potentials that can be harnessed in various industries.

acetone extract, Bioactive compounds, Daedalea elegans, GC-MS analysis.

[1] Manzi, P., Aguzzi, A. and Pizzoferrato, L. Nutritional value of mushrooms widely consumed in Italy. Food Chemistry.2001, 00 73, pp. 321-325.
[2] Oei, P. Mushroom cultivation 3rd Edition. Appropriate Technology for mushroom growers. Backhuys Publishers, Leiden, The Netherlands, 2003.
[3] Jonathan, S.G.,Amos-Tautina B.M.V. and Olawuyi, O. J. Detection of exopolysaccharides in Lentinus squarrosulus (Berk.), a Nigerian mushroom. African Journal of Agricultural Research, 2011, 6(13), pp. 3007-3012.
[4] Kumari, D., Reddy, M.S. and Upadhyay, R.C. Nutritional composition and antioxidant activities of 18 different wild Cantharellus mushrooms of Northwestern Himalayas. Food Science and Technology International, 2011, 17 pp.557-567.
[5] Yang, J. H., Lin, H. C. and Mau, J. L. Non-volatile taste components of several commercial mushrooms. Food Chemistry, 2001, 72, pp. 465–471
[6] Jonathan, S.G. and Fasidi, I.O. Antimicrobial activities of two Nigerian edible macro fungi – Lycoperdonpusilum (Bat. Ex) and Lycoperdon giganteus (Pers). African Journalof Biomedical Research, 2003,6(2), pp.85 –90.
[7] Jonathan, S.G., Kigigha, L.T. and Ohimain, E. Evaluation of the Inhibitory Potentials of Eight Higher Nigerian Fungi against Pathogenic Microorganisms. African Journal of Biomedical Research, 2008, 11, pp. 197-202
[8] Olawuyi, O.J., Jonathan, S.G., Aina, D.A. and Baysah, G.I. Studies on antibacterial activities ofFomes lignosus -A Nigerian mushroom. Nigerian Journal of Microbiology.2010, 24(1), pp. 2153-2159.
[9] Aina, D.A., Olawuyi, O.J., Mensah-Agyei, G.O., Olaiya, A.R. and Adeoye-Isijola, M.O. Comparativephytochemical evaluation, antimicrobial and antioxidant properties of methanolic and ethanolic extracts of Daedalea elegans- A Nigerian Mushroom. Advance Pharmaceutical Journal.2016, 1(2) pp. 38-42
[10] Zoberi, M.H. Some Edible mushrooms from Nigeria. Nigeria Fields1978, 38, pp. 81 – 90
[11] Alexopoulous, C.J., Mims C.W. and Blackwell, M. Introductory Mycology. 4th ed. John Wiley and Sons. New York, Chichester, Brisbane, Toronto and Singapore. 1996.
[12] Indrayanto, G., Syahrani, A., Mugihardjo, Rahman, A., Soeharjono, Tanudjojo, W., Susanti, S., Yuwono, M. and Ebel, S. Benzoic Acid. Analytical Profiles of Drug Substances and Excipients.1999,26 pp. 1-46
[13] Rowe, R.C., Sheskey, P.J. and Quinn, M.E.; (Eds.), Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press, London, England 2009, pp. 61
[14] Anneken, D.J., Both, S., Christoph, R., Fieg, G., Steinberner, U. and Westfechtel, A. "Fatty Acids" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim. 2006. doi:10.1002/14356007.a10_245.pub2
[15] Chang, P., Terbach, N., Plant, N., Chen, P.E., Walker, M.C. and Williams, R.S. Neuropharmacology. 2013. 69:105–114. doi:10.1016/j.neuropharm.2012.11.004
[16] Bull, J.A., Croft, R.A., Davis, O.A., Doran, R. and Morgan, K.F. Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry. Chemical Reviews, 2016, 116(19), pp.12150–12233
[17] Sharma, U., Kumar, P., Kumar, N. and Singh, B. Recent Advances in the Chemistry of Phthalimide Analogues and Their Therapeutic Potential. Mini-Reviews in Medicinal Chemistry,2010,10(8), pp. 678-704. doi:10.2174/138955710791572442
[18] Kushwahaa, N. and Kaushik, D. Recent Advances and Future Prospects of Phthalimide Derivatives. Journal of Applied Pharmaceutical Science.2016, 6(03), pp. 159-171
[19] Dr. Duke’s. Phytochemical and Ethnobotanical Databases, Phytochemical and Ethnobotanical, Databases. www.ars-gov/cgi-bin/duke/. 2020
[20] Dwivedi, D., Khandelwal, G., Patidar, R.K. and Sing, V. Antimicrobial Activity of Mentha arvensis against Clinical Isolates of Human Cariogenic Pathogens- An In-Vitro Study. International Journal of Pharmaceutical Sciences and Research. 2012,3(5), pp.1355-1360
[21] Pedersen, H.K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T. et al., Human gut microbes impact host serum metabolome and insulin sensitivity. Nature. 2016, 535:376–381.
[22] Forouhi, N.G., Koulman, A., Sharp, S.J., Imamura, F., Kröger, J. et al., Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study. Lancet Diabetes Endocrinology.2014,2(10), pp. 810-8. doi: 10.1016/S2213-8587(14)70146-9.
[23] Henry, G.E., Momin, R.A., Nair, M.G. and Dewitt, D.L. Antioxidant and Cyclooxygenase activities of Fatty Acids Found in Food. Journal of Agricultural and Food Chemistry. 2002, 50, pp. 2231-2234
[24] Praveen, K.P., Kumaravel, S. and Lalitha, C. Screening of Antioxidant Activity, Total phenolics and GC-MS study of Vitex negundo. African Journal of Biochemical Research. 2010, 4(7) pp. 191-195.
[25] Mensah-Agyei, G.O., Ayeni, K.I., and Ezeamagu, C.O. GC-MS analysis of bioactive compounds and evaluation of antimicrobial activity of the extracts of Daedalea elegans: A Nigerian mushroom. African Journal of Microbiology Research,2020, 14(6), pp. 204-210. https://doi.org/10.5897/AJMR2019.9120
[26] Rowdhwal, S. and Chen, J. Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview. BioMed Research International. 2018, 18, pp. 1-10. doi:10.1155/2018/1750368.
[27] David, O.M., Fagbohun, E.D., Oluyege, A.O. and Adegbuyi, A. Antimicrobial activity and physiochemical property of oils from tropical macrofungi. Journal of Yeast and Fungal Research. 2012, 3(1), pp. 1-6.
[28] Badea, G.I. and Radu, G.L. Introductory Chapter: Carboxylic Acids - Key Role in Life Sciences. 2018.doi: 10.5772/intechopen.77021