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International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

Crispr-Cas9 Gene Editing: Ethical Considerations and Future Applications

Jalla Ram

International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-6,Issue-5, September - October 2022, Pages 16-20 , 10.22161/ijmpd.6.5.4

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Article Info: Received: 25 Aug 2022; Received in revised form: 20 Sep 2022; Accepted: 28 Sep 2022; Available online: 08 Oct 2022


CRISPR-Cas9 gene editing has emerged as a revolutionary technology with the potential to transform genetic research, medical treatments, and agriculture. Its unparalleled precision in modifying DNA sequences offers exciting opportunities for addressing genetic diseases and advancing scientific knowledge. However, this transformative power brings forth profound ethical considerations that resonate through medical, societal, and environmental realms. This abstract encapsulates an exploration of the ethical dimensions of CRISPR-Cas9 gene editing and its future applications. The advent of CRISPR-Cas9 gene editing has ushered in a new era of genetic manipulation, promising to reshape the boundaries of medicine, agriculture, and scientific understanding. This technology enables precise modifications to DNA sequences, offering a revolutionary means to correct genetic defects, enhance traits, and potentially revolutionize various fields. However, its immense potential is accompanied by a cascade of ethical concerns that require in-depth examination. CRISPR-Cas9 gene editing poses fundamental ethical dilemmas that intersect with human values, societal norms, and our understanding of nature. The ability to directly alter genetic material prompts questions about playing with the very essence of life. Concerns about unintended consequences, potential genetic enhancement, and the moral implications of altering the human germline weigh heavily on the ethical scales.

Ethical, Human germline, environmental, transform, Genetic.

[1] Ayanoğlu, Fatma Betül et al. “Bioethical issues in genome editing by CRISPR-Cas9 technology.” Turkish journal of biology = Turk biyoloji dergisi vol. 44,2 110-120. 2 Apr. 2020, doi:10.3906/biy-1912-52
[2] Cribbs, Adam P, and Sumeth M W Perera. “Science and Bioethics of CRISPR-Cas9 Gene Editing: An Analysis Towards Separating Facts and Fiction.” The Yale journal of biology and medicine vol. 90,4 625-634. 19 Dec. 2017
[3] Rodriguez E (2016) Ethical Issues in Genome Editing using Crispr/Cas9 System. J Clin Res Bioeth 7: 266. doi: 10.4172/2155-9627.1000266
[4] Gostimskaya, I. CRISPR–Cas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing. Biochemistry Moscow 87, 777–788 (2022).
[5] Jodie Rothschild BA, Ethical considerations of gene editing and genetic selection, Journal of General and Family Medicine, Volume 21, Issue 3, May 2020, Pages 37-47
[6] Liting You, Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research, Molecular Therapy: Methods & Clinical Development Vol. 13 June 2019
[7] Richardson, C.D., Ray, G.J., DeWitt, M.A., Curie, G.L., and Corn, J.E. (2016). Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA. Nat. Biotechnol. 34, 339–344.
[8] Bycroft, C., Freeman, C., Petkova, D., Band, G., Elliott, L.T., Sharp, K., Motyer, A., Vukcevic, D., Delaneau, O., O’Connell, J., et al. (2018). The UK Biobank resource with deep phenotyping and genomic data. Nature 562, 203–209.
[9] Liu, S., Huang, S., Chen, F., Zhao, L., Yuan, Y., Francis, S.S., Fang, L., Li, Z., Lin, L., Liu, R., et al. (2018). Genomic Analyses from Non-invasive Prenatal Testing Reveal Genetic Associations, Patterns of Viral Infections, and Chinese Population History. Cell 175, 347–359.
[10] Eisenstein, M. (2017). An ace in the hole for DNA sequencing. Nature 550, 285–288.
[11] Adams, D.R., and Eng, C.M. (2018). Next-Generation Sequencing to Diagnose Suspected Genetic Disorders. N. Engl. J. Med. 379, 1353–1362.
[12] Habib, N., Avraham-Davidi, I., Basu, A., Burks, T., Shekhar, K., Hofree, M., Choudhury, S.R., Aguet, F., Gelfand, E., Ardlie, K., et al. (2017). Massively parallel single-nucleus RNA-seq with DroNc-seq. Nat. Methods 14, 955–958.
[13] Wagner, D.L., Amini, L., Wendering, D.J., Burkhardt, L.M., Akyüz, L., Reinke, P., Volk, H.D., and Schmueck-Henneresse, M. (2019). High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population. Nat. Med 25, 242–248.
[14] Chu, V.T., Weber, T., Wefers, B., Wurst, W., Sander, S., Rajewsky, K., and Kühn, R. (2015). Increasing the efficiency of homology-directed repair for CRISPR-Cas9- induced precise gene editing in mammalian cells. Nat. Biotechnol. 33, 543–548.