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International Journal Of Medical, Pharmacy And Drug Research(IJMPD)

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  3. Vol-5,Issue-2, March - April 2021
  4. Bronchus Histology of Wistar Rats (Rattus norvegicus L) that are exposed to the cigarette smokes given with Angel's Tears leaves (Brugmansia suaveolens) smoke treatment

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Bronchus Histology of Wistar Rats (Rattus norvegicus L) that are exposed to the cigarette smokes given with Angel's Tears leaves (Brugmansia suaveolens) smoke treatment

Tanty. F Audria , Sri. Isdadiyanto , Sunarno Sunarno


International Journal of Medical, Pharmacy and Drug Research(IJMPD), Vol-5,Issue-2, March - April 2021, Pages 4-9 , 10.22161/ijmpd.5.2.2

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Article Info: Received: 03 Dec 2020; Received in revised form: 19 Jan 2020; Accepted: 21 Feb 2021; Available online: 25 Mar 2021

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Angel's tears (Brugmansia suaveolens Bercht. & Presl) contain tropane alkaloids, such as atropine, hyoscyamine and scopolamine which have anticholinergics potential. This study aims to analyze the effect of Angel's tears leaf smoke on the thickness of the mucous-submucosal membrane and the number of bronchial goblet cells of white rats induced by cigarette smoke exposure. Two months old male Wistar rats (Rattus norvegicus L.) were used (average weight 200 g). This study was an experimental study with a completely randomized block design consisting of 5 treatments and 4 replications, namely K0: negative control, K1: Positive control was given exposure to 1 cigarette / day, P3: K1 + Aminophylline 8.1 mg / 200 g BW, and two treatment groups (P1, P2) were given the smoke of Angel's tears with different doses. White rat bronchi were prepared for histological observation using the paraffin method and Hematoxylin-Eosin staining. Data analysis using ANOVA followed by Duncan's Multiple Range Tests with a confidence level of 95%. The results showed that the smoke of Angel's tears can reduce the thickness of the mucous-submucous membrane and the number of goblet cells in white rats. This study provides information to the public that Angel's tears can be used as an alternative treatment for respiratory disease.

Brugmansia suaveolens, cigarette smoke, goblet cells, mucosal-submucosal membrane thickness

[1] S. M. S. Islam, T. D. Purnat, N.T. Anh Phuong, U. Mwingira, K. Schacht, G. Fröschl, “Non Communicable Diseases (NCDs) in developing countries: A symposium report,” Globalization and Health., vol. 10, 2014, pp. 1–7.
[2] M. D. Eisner, N. Anthonisen, D. Coultas, N. Kuenzli, R. Perez-Padilla, D. Postma, I. Romieu, E. K. Silverman, J. R. Balmes, “An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease”, American Journal of Respiratory and Critical Care Medicine,. vol 182, 2010, pp. 693–718.
[3] S. Wenny, “Bahaya Merokok Bagi Kesehatan,” UMM., vol. 1, 2010, pp. 1-8.
[4] R.V. Suryadinata., A. Lorensia, R. K. Sari, “ Differences in Nutrition Food Intake and Body Mass Index between Smoker and Non-smoker in Adult Indones,” J. Clin. Pharm., vol. 6, 2017, pp. 171–180
[5] M. Silva, and P. Bercik, “ Blood, Lymphatics, Immune System and Stem Cells. Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells,” Laboratory Investigation., vol. 92, 2012, pp. 937 – 948.
[6] A. Rohmani, “The Effects of Kersen Fruit Extract (Muntingia Calabura) on the Number of Bronchial Ciliated Epithellium Cells on Cigarette Smoke Exposed Wistar Rats”J. Faculty Medicine Muhammadiyah University of Semarang., vol. 1, 2018, pp.1-8.
[7] A. Lorensia, “Efektivitas dan Risiko Toksisitas Aminofilin Intravena pada Pengobatan Awal Serangan Asma,” Jurnal Farmasi Klinik Indonesia., vol. 7, 2012, pp. 8-18.
[8] Triyani, “Evaluasi Penggunaan Obat Asma Pada Pasien Asma Di Instalasi Rawat Inap Rsup Dr. Soeradji Tirtonegoro Klaten Tahun 2009,” Faculty Medicine Muhammadiyah University of Semarang., vol. 1, 2020, pp.21.
[9] Na’i, A, Y. Rakanita, and S. Mulyani, “Uji Efek Kombinasi EEDS dan DPW terhadap Penurunan Kadar Kolesterol Total Tikus Putih Jantan Hiperkolesterolemia-Diabetes,” Farmakologika Jurnal Farmasi., vol. 16, 2019, pp. 1–12.
[10] N.I. Anisa, S. A. Mutiara, A. S. Andreanus, “ Uji efek antiinflamasi ekstrak air daun Angel’s tears gunung [brugmansia suaveolens [humb. & bonpl. Ex willd] bercht. & presl] pada tikus wistar betina,” Jurnal Ilmiah Farmasi., vol. 2, 2015, pp.21-27.
[11] M. Aria, Verawati, A. Arel, and Monika, “Uji efek antiinflamasi fraksi daun piladang (solenostemonscutellarioides (l.) Codd) terhadap mencit putih betina,” Scientia., vol. 5, 2015, pp. 84-91.
[12] Unitly, Adrien, Jems, Akiles, N. Kusumorini, S.Agungpriyono, A. S. Satyaningtijas, A. Boediono, “Analisis mikroskopis paru-paru tikus jantan (rattus norvegicus)”., Journal Unsyiah., vol. 1, 2018, pp. 9.
[13] J. Sitasiwi, S. Isdadiyanto, and S. M. Mardiati, “The Estradiol 17- β Concentration in Mice After Treated with Ethanolic Leaf Extract of Azadirachta indica (Neem),” The 18th International Conference on Positron Annihilation., vol. 020014, 2017, pp. 1–8.
[14] Muhartiningsih, “Perbandingan Pengaruh Pendedahan Uap Bensin Jenis Pertamax Dan Premium Terhadap Gambaran Histologi Bronkus Tikus Putih (Rattus Norvegicus) Jantan,” Magna Medika., vol 6, 2019, pp. 1-5.
[15] L. Rahmad, “Pengaruh Pemberian Ekstrak Rimpang Kunyit (Curcuma Domestica Val.) terhadap Gambaran Histopatologis Paru-Paru yang Diinduksi Asap Rokok pada Tikus Putih Wistar,” Kedokteran Hewan., vol. 1, 2018, pp. 9.

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