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International Journal Of Chemistry, Mathematics And Physics(IJCMP)

The Impacts of Viral Hepatitis on Liver Enzymes and Bilrubin

Dr. Noaman Abdulateef Abdulrazzaq , Mustafa Mamon Ahmed , Farah Thamer Hasan , Dr. Faisal Challab Hasson


International Journal of Chemistry, Mathematics And Physics(IJCMP), Vol-6,Issue-6, November - December 2022, Pages 1-6 , 10.22161/ijcmp.6.6.1

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Article Info: Received: 16 Oct 2022; Received in revised form: 03 Nov 2022; Accepted: 08 Nov 2022; Available online: 12 Nov 2022

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Viral hepatitis is an infection that causes liver inflammation and damage. Several different viruses cause hepatitis, including hepatitis A, B, C, D, and E. The hepatitis A and E viruses typically cause acute infections. The hepatitis B, C, and D viruses can cause acute and chronic infections. Hepatitis A causes only acute infection and typically gets better without treatment after a few weeks. The hepatitis A virus spreads through contact with an infected person’s stool. Protection by getting the hepatitis A vaccine. Hepatitis E is typically an acute infection that gets better without treatment after several weeks. Some types of hepatitis E virus are spread by drinking water contaminated by an infected person’s stool. Other types are spread by eating undercooked pork or wild game. Hepatitis B can cause acute or chronic infection. Recommendation for screening for hepatitis B in pregnant women or in those with a high chance of being infected. Protection from hepatitis B by getting the hepatitis B vaccine. Hepatitis C can cause acute or chronic infection. Doctors usually recommend one-time screening of all adults ages 18 to 79 for hepatitis C. Early diagnosis and treatment can prevent liver damage. The hepatitis D virus is unusual because it can only infect those who have a hepatitis B virus infection. A coinfection occurs when both hepatitis D and hepatitis B infections at the same time. A superinfection occurs already have chronic hepatitis B and then become infected with hepatitis D. The aim of this study is to find the effect of each type of viral hepatitis on the bilirubin (TB , DSB) , and liver enzymes; AST, ALT, ALP,GGT among viral hepatitis patients. 200 patients were selected from the viral hepatitis units in the central public health laboratory in Baghdad city, all the chosen cases were confirmed as a positive samples , they are classified into four equal group each with fifty individual and with a single serological viral hepatitis type either; anti-HAV( IgM ) , HBs Ag , anti-HCV ,or anti-HEV(IgM ). All patients were tested for; serum bilirubin ( TB ,D.SB ) , AST , ALT , ALP , GGT. Another fifty quite healthy and normal person was selected as a control group for comparison. . Liver enzymes and bilirubin changes are more pronounced in HAV, HEV than HCV and HBVAST and ALT lack some sensitivity in detecting HCV ,HBV and mild elevations of ALT or AST in asymptomatic patients can be evaluated efficiently by considering ,hepatitis B, hepatitis C. ALT is generally a more sensitive indicator of acute liver cell damage than AST, It is relatively specific for hepatocyte necrosis with a marked elevations in viral hepatitis. Liver enzymes and bilirubin changes are more pronounced in HAV, HEV than HCV and HBV.AST and ALT lack some sensitivity in detecting HCV ,HBV and mild elevations of ALT or AST in asymptomatic patients can be evaluated efficiently by considering ,hepatitis B, hepatitis C. ALT is generally a more sensitive indicator of acute liver cell damage than AST, It is relatively specific for hepatocyte necrosis with a marked elevations in viral hepatitis.

viral hepatitis, liver enzyme.

[1] Green RM, Flamm S. AGA technical review on the evaluation of liver chemistry tests. Gastroenterology 2002;123(4):1367-84. [PubMed]
[2] Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB. Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests. Clin Chem 2000;46(12):2027-49. [PubMed]
[3] Fogden E, Neuberger J. Alternative medicines and the liver. Liver Int 2003; 23 (4): 213-20. [PubMed]
[4] Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004; 11 (2): 97-107. [PubMed]
[5] El Gawhary S, Omar N, Abdel Rahman L, Mahmoud M. Hepatic viruses screening in multitransfused Egyptian thalassemia patients. J Arab Child. 2009;20(3):193–202. [Google Scholar]
[6] Ameli M, Besharati S, Nemati K, Zamani F. Relationship between elevated liver enzyme with iron overload and viral hepatitis in thalassemia major patients in Northern Iran. Saudi Med J. 2008;29(11):1611–5. [PubMed] [Google Scholar]
[7] Ardalan FA, Osquei MR, Toosi MN, Irvanloo G. Synergic effect of chronic hepatitis C infection and beta thalassemia major with marked hepatic iron overload on liver fibrosis:a retrospective cross-sectional study. BMC Gastroenterol. 2004;4:17. [PMC free article] [PubMed] [Google Scholar]
[8] Feld J, Lee JY, Locarnini S. New targets and possible new therapeutic approaches in the chemotherapy of chronic hepatitis B. Hepatology. 2003;38(3):545–53. [PubMed] [Google Scholar]
[9] Khalifa AS, El-Sayed MH, Moustafa AO, Mohammed MM, Rady MS, Salama II. Hepatitis C virus infection in children with hematological diseases:risk factors and reliability of diagnosis assays. Egypt J Pediatr. 2002;19:293–308. [Google Scholar]
[10] El-Faramawy A, El-Rashidy O, Tawfik P, Hussein G. Transfusion Transmitted Hepatitis:Where Do We Stand Now? A One Center Study in Upper Egypt. Hepat Mon. 2012;12(4):286–291. [PMC free article] [PubMed] [Google Scholar]
[11] Angelucci E, Muretto P, Nicolucci A, Baronciani D, et al. Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation. Blood. 2002;100:17–21. [PubMed] [Google Scholar]
[12] Di Marco V, Capra M, Gagliardotto F, Borsellino Z, et al. Liver disease in chelated transfusion-dependent thalassemics:the role of iron overload and chronic hepatitis C. Haematologica. 2008;93(8):1243–1246. [PubMed] [Google Scholar]
[13] Edoardo G, Testa R, Savarino V. Liver enzyme alteration:a guide for clinicians. CMAJ. 2005;172(3):367–379. [PMC free article] [PubMed] [Google Scholar]