IJCMP | New Method for Spectrophotometric Determination of Furosemide in Pure Form and in Pharmaceutical Formulations

Indexing and Abstracting

New Method for Spectrophotometric Determination of Furosemide in Pure Form and in Pharmaceutical Formulations

Malek MS Okdeh , Alaa Aljalfah

International Journal of Chemistry, Mathematics And Physics(IJCMP), Vol-7,Issue-2, March - April 2023, Pages 6-12 , 10.22161/ijcmp.7.2.2

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Article Info: Received: 12 Mar 2023; Received in revised form: 11 Apr 2023; Accepted: 18 Apr 2023; Available online: 25 Apr 2023

Abstract:

An accurate, simple, fast and cheap spectrophotometric method has been developed for the determination of Furosemide (FUR) in pharmaceutical pure and dosage forms. The method is based on the reaction of 2,4- Di hydroxyl Benz aldehyde (DHBA) with Furosemide in the presence of Ethyl alcohol. This reaction produces a complex yellow colored product which absorbs maximally at 430 nm. Beer’s law was obeyed in the range of 3.3 – 82.69 μg/mL with molar absorptivity of 1.749×103 L mole-1 cm-1 Sandell’s sensitivity 0.11 μg.cm-2. The effects of variables such as temperature, concentration of color producing reagent, and stability of color were investigated to optimize the procedure. The results are validated statistically. The proposed method was applied to commercially available tablets, and the results were Pharmaceutical formulations.

Keywords:

Furosemide; 2,4 Di hydroxyl Benz aldehyde; Spectrophotometry; Beer’s law; complex.

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