IJCMP | Evaluation of In-vitro neuroprotective effect of Ethanolic extract of Canarium solomonensee Leaves on H2O2 induced toxicity in SH-SY5Y cell line

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Evaluation of In-vitro neuroprotective effect of Ethanolic extract of Canarium solomonensee Leaves on H2O2 induced toxicity in SH-SY5Y cell line

Patil Hansraj Annarao , Shaktikumar Chandrashekhar Shivhare

International Journal of Chemistry, Mathematics And Physics(IJCMP), Vol-8,Issue-1, January - March 2024, Pages 1-4 ,

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Article Info: Received: 17 Nov 2023; Received in revised form: 21 Dec 2023; Accepted: 03 Jan 2023; Available online: 10 Jan 2024

Abstract:

The ethanolic extract of canarium solomonense leaves (ecsl) was studied for its neuroprotective activity. The neuroprotective activity of ECSL was found to have a significant impact on neuronal cell death triggered by hydrogen peroxide (MTT assay) in human SH-SY5Y neuroblastoma cells. Scopolamine, a muscarinic receptor blocker, is frequently used to induce cognitive impairment in laboratory animals. Injections of scopolamine influence multiple cognitive functions, including motor function, short-term memory, and attention. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, memory enhancing activity in scopolamine-induced amnesic rats was evaluated. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, ECSL was found to have a substantial effect on the memory of scopolamine- induced amnesic rats. Our experimental data indicated that ECSL can reverse scopolamine induced amnesia and assist with memory issues.

Keywords:

Canarium solomonense, Neuroprotective Activity, Hydrogen Peroxide, Scopolamine-induced Amnesia, Memory Enhancement

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