IJCGM | Synthesis and Antibacterial Studies of Fe(II), Co(II), Ni(II) and Cu(II) Complexes of Lumefantrine

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Synthesis and Antibacterial Studies of Fe(II), Co(II), Ni(II) and Cu(II) Complexes of Lumefantrine

O.K. Amadi , I.E. Otuokere , N.C. Chinedum

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Journal : International journal of Horticulture, Agriculture and Food science(IJHAF)

Abstract:

Effect of metal complexation on the spectra and bactericidal activity of lumefantrine was carried out. The synthetic technique was based on the modification of lumefantrine by the introduction of metal ions into the molecular structures of the drug. Four metal complexes derived from the ligand lumefrantine was synthesized using the following metal ions Fe(II), Ni(II), Cu(II) and Co(II). The melting point, solubility and colour of the complexes were determined. The complexes were characterized based on electronic and infrared spectroscopy. The infrared spectroscopy revealed significant shift in ѵ(O-H), ѵ(M-N) and ѵ(C-N) and were used to proposed the structures of the complexes. The UV-Visible spectra shows the π-π* absorptions due to the aromatic compound of lumefantrine and ligand to metal change transfer (LMCT) in the complexes. The results of the antibacterial activities of lumefantrine complexes against Streptococcus pneumonia and Shigella dysenteriae revealed that the zone of inhibition of lumefantrine at 500, 250 and 125 mg/ml were significantly lower (P < 0.05) than the complexes. Lumefantrine behaved as a bidentate ligand with Fe(II), Cu(II) and Ni(II) and behaved as a monodentate ligand with Co(II). The complexes exhibited higher antigrowth activity against the bacteria species than the free ligand. Thus it can be inferred that the lipophilic property of the complexes enhanced absorption of compounds to their target sites of action.

Keywords:

ligand, Lumefantrine, Shigella dysenteriae, spectroscopy, Streptococcus pneumonia.

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